This category is for supervillains in the DC Universe. This includes current and former supervillains.
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- Sally Sonic
- Sea King
- Silver Swan
- Silver Swan (Vanessa Kapatelis)
- Sinestro
- Slipknot
- Sobek
- Solomon Grundy
- Spencer Spencer (Lois and Clark: The New Adventures of Superman)
- Spider (DC Comics)
- Sportsmaster
- Star Sapphire
- Star Sapphire (Dela Pharon)
- Star Sapphire (Jillian Pearlman)
- Star Sapphire (Remoni-Notra)
- Starling
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- Super-Woman
- Superboy Prime
- Superman Revenge Squad
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- Superwoman
- Superwoman (Disambiguation)
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