Not much is known about this villain, but she and her sidekick, Bun-Bun, stole multiple supplies meant for babies in order to power her giant baby bottle shaped ray in order to turn everyone in Big Bubble City into babies. But when she needs to turn individual people into babies, she uses a smaller scale version of her ray. When Bubble Boy and Guppy Girl arrived to stop her, she managed to turn Bubble Boy into a baby. However, she was defeated when Guppy Girl was joined by her baby sister Bubble Baby and got her giant robotic baby to fall asleep, causing it to drop the bottle shaped ray and destroy it. She and Bun-Bun were then sent to Big Bubble City Jail.
- Miss Goo-Goo is voiced by music legend, Cindy Lauper.